2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-PEG3-N3

(S,R,S)-AHPC-PEG3-N3  (Synonyms: VH032-PEG3-N3; VHL Ligand-Linker Conjugates 8; E3 ligase Ligand-Linker Conjugates 12)

Cat. No.: HY-103598 Purity: 99.67%
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(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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(S,R,S)-AHPC-PEG3-N3 Chemical Structure

(S,R,S)-AHPC-PEG3-N3 Chemical Structure

CAS No. : 1797406-80-4

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Based on 1 publication(s) in Google Scholar

(S,R,S)-AHPC-PEG3-N3 Related Antibodies

Top Publications Citing Use of Products

View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target[1]

VHL

 

In Vitro

(S,R,S)-AHPC-PEG3-N3 is extracted from patent WO/2016/146985A1, figure 11. PROTAC has been developed having structure A-L-B that can tether a bromodomain inhibitor via a moiety which binds to a protein within the bromo- and Extra-terminal (BET) family of proteins to a small molecule E3 ubiquintin ligase protein binding ligand compond via a suitable linker[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R,S)-AHPC-PEG3-N3 Related Antibodies
Molecular Weight

645.77

Formula

C30H43N7O7S
CAS No.
Appearance

Solid-Liquid Mixture

SMILES

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (154.85 mM; Need ultrasonic)

H2O : ≥ 100 mg/mL (154.85 mM)

DMSO : 50 mg/mL (77.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5485 mL 7.7427 mL 15.4854 mL
5 mM 0.3097 mL 1.5485 mL 3.0971 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.67%

SDS (393 KB)

COA (251 KB) HNMR (123 KB) LCMS (279 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Ethanol / H2O 1 mM 1.5485 mL 7.7427 mL 15.4854 mL 38.7135 mL
5 mM 0.3097 mL 1.5485 mL 3.0971 mL 7.7427 mL
10 mM 0.1549 mL 0.7743 mL 1.5485 mL 3.8713 mL
15 mM 0.1032 mL 0.5162 mL 1.0324 mL 2.5809 mL
20 mM 0.0774 mL 0.3871 mL 0.7743 mL 1.9357 mL
25 mM 0.0619 mL 0.3097 mL 0.6194 mL 1.5485 mL
30 mM 0.0516 mL 0.2581 mL 0.5162 mL 1.2904 mL
40 mM 0.0387 mL 0.1936 mL 0.3871 mL 0.9678 mL
50 mM 0.0310 mL 0.1549 mL 0.3097 mL 0.7743 mL
60 mM 0.0258 mL 0.1290 mL 0.2581 mL 0.6452 mL
Ethanol / H2O 80 mM 0.0194 mL 0.0968 mL 0.1936 mL 0.4839 mL
100 mM 0.0155 mL 0.0774 mL 0.1549 mL 0.3871 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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(S,R,S)-AHPC-PEG3-N3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-PEG3-N31797406-80-4VH032-PEG3-N3 VHL Ligand-Linker Conjugates 8 E3 ligase Ligand-Linker Conjugates 12E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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